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Human reproductive endocrine effects of occupational solvent exposure.

Authors
Faustman-EM; Luderer-U; Brodkin-CA; Kalman-D; Morgan-MS
Source
NIOSH 2000 Feb; :1-19
Link
NIOSHTIC No.
20023732
Abstract
Although organic solvents are widely used in many different industries, there is very little data on the effects of exposure to all but a few solvents on male reproductive health. Painters comprise one large occupational group with significant solvent exposure that has not been wellstudied in this regard. We therefore chose to study fertility and reproductive endocrine function in male painters. We assessed time-to-pregnancy (fecundability, an indicator of fertility) using a retrospective cohort design and cross-sectionally measured reproductive hormone concentrations in a group of painters compared to a control group of carpenters and to a group of millwrights with intermediate solvent exposure. Detailed occupational, exposure, medical, and time-topregnancy histories were obtained by telephone interview using previously validated instruments. Blood samples were obtained, and serum luteinizing hormone (LH), follic1estimulating hormone (FSH), and testosterone concentrations were determined by immunoassay. Whole blood lead was also measured. Using Cox regression analysis we found that time-topregnancy was non-significantly longer in the painters and millwrights than the carpenters (relative probability of pregnancy in the painters and millwrights combined compared to the carpenters of 0.76, 95% CI 0.45-1.27). In the multivariate analysis time-to-pregnancy was significantly affected by age of the father at the time of the pregnancy of interest and whether the couple was trying to become pregnant. Using analysis of covariance, LH, FSH, and testosterone concentrations did not differ by exposure group, but LH varied significantly with body mass index and education, and testosterone varied significantly with body mass index. The nonsignificantly reduced fecundability in the two solvent-exposed groups suggests the need for further study of fertility in solvent-exposed men.
Keywords
Endocrine-system-disorders; Reproductive-effects; Reproductive-system-disorders; Painters; Men; Organic-solvents; Fertility; Hormones; Blood-sampling; Occupational-exposure; Statistical-analysis; Epidemiology; Exposure-limits; Toluenes
Contact
University of Washington, Department of Environmental Health, Seattle, WA 98105
CAS No.
108-88-3; 1330-20-7; 111-65-9; 78-93-3; 123-86-4; 8052-41-3
Publication Date
20000228
Document Type
Final Grant Report
Funding Amount
69239
Funding Type
Grant
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R03-OH-003468
NIOSH Division
OEP
Priority Area
Disease and Injury: Fertility and Pregnancy Abnormalities
Source Name
National Institute for Occupational Safety and Health
State
WA; CA
Performing Organization
University of Washington, Department of Environmental Health, Seattle, Washington
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