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Models for assessing risk of occupational hearing loss.

Authors
Fechter-LD
Source
NIOSH 2000 Nov :1-9
Link
NIOSHTIC No.
20023718
Abstract
The research undertaken under this grant was designed to determine the ability of the chemical asphyxiants, carbon monoxide and cyanide, to potentiate noise induced hearing loss. Such mixed exposure to noise and asphyxiant can be predicted to occur in a number or workplace settings such as those that firefighters and truck drivers experience. The results of experiments conducted in rats demonstrate that these asphyxiants do potentiate noise induced hearing loss in a concentration dependent fashion and with an estimated lower bound benchmark concentration of approximately 200-300ppm. Asphyxiants may also increase vulnerability under conditions of intermittent noise exposure. A probable mechanism responsible for potentiation of noise induced hearing loss by asphyxiants is enhancement of free radical species with subsequent tissue damage.
Keywords
Noise-induced-hearing-loss; Chemical-reactions; Ototoxicity; Hearing-loss; Noise-exposure; Free-radical-generation; Free-radicals; Tissue-disorders
Contact
University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, P.O. Box 26901, Oklahoma City, OK 73190
CAS No.
630-08-0; 74-90-8
Publication Date
20001127
Document Type
Final Grant Report
Funding Amount
561752
Funding Type
Grant
Fiscal Year
2001
NTIS Accession No.
PB2004-104023
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-003481
NIOSH Division
OEP
Priority Area
Disease and Injury: Hearing Loss
Source Name
National Institute for Occupational Safety and Health
State
OK
Performing Organization
University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, Oklahoma City, Oklahoma
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