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Lead, solvents, and neurobehavior in construction workers.

Authors
Fiedler-NL; Gochfeld-M; Wedeen-R; Weisel-C
Source
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-003144, 1998 Jul; :1-119
Link
NIOSHTIC No.
20023677
Abstract
Construction workers are routinely exposed to hazards including neurotoxicants with little or no protection or medical monitoring of health effects. Neurobehavioral tests of cognition, sensory function, and mood were compared between the following four groups of construction workers who were members of the International Association of Bridge, Structural and Ornamental Iron Workers or International Brotherhood of Painters and Allied Trades (IBPAT): Lead (N= 38); Lead/Solvent (N=40); Solvent (N = 46); Controls (N= 42). Groups were matched on age, education, intellectual ability, alcohol and drug use, gender, and ethnicity. Average bone lead was comparable between the Lead and Lead/Solvent groups with a mean of 14.4 ppm (S.D. = 19.0) and 19.5 ppm (S.D. = 11.4), respectively. Lifetime solvent exposure estimates were significantly higher in the Solvent and Lead/Solvent groups which did not differ from each other. Memory function was significantly reduced for the exposed .groups relative to the Controls. Relative to Controls, the Solvent group had reduced verbal memory while the Lead exposed group had increased latency of response on a coding task involving visuospatial memory. Lead and solvent exposure did not have a synergistic or additive effect on cognitive performance. Bone lead was a significant predictor of latency of response for the coding task while lifetime solvent exposure was a significant predictor of verbal memory performance. Sensory losses included reduced contrast sensitivity for the Solvent group relative to a matched group of Controls, while hearing loss was documented for the Lead group, composed primarily of Iron Workers. Significant reductions in bone lead were documented at a 2 year follow-up and some improvement in functions of attention/concentration were also seen.
Keywords
Lead-compounds; Lead-dust; Solvents; Behavior; Behavior-patterns; Construction-industry; Construction-workers; Occupational-exposure; Occupational-hazards; Hazards; Neurotoxins; Demographic-characteristics
Contact
University of Medicine and Dentistry of New Jersey Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Road, Piscataway, NJ 08854
CAS No.
7439-92-1
Publication Date
19980701
Document Type
Final Grant Report
Funding Amount
798424
Funding Type
Grant
Fiscal Year
1998
NTIS Accession No.
PB2015-100618
NTIS Price
A07
Identifying No.
Grant-Number-R01-OH-003144
NIOSH Division
OEP
Source Name
National Institute for Occupational Safety and Health
State
NJ
Performing Organization
University of Medicine and Dentistry of New Jersey Environmental and Occupational Health Sciences Institute, Piscataway, NJ
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