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Toxicokinetics of ethyl tertiary-butyl ether (ETBE) and methyl tertiary-butyl ether (MTBE) in men and women.

Authors
Pierce-CH
Source
NIOSH 2001 May; :1-39
Link
NIOSHTIC No.
20023640
Abstract
Methyl tertiary butyl ether (MTBE) and ETBE are used as gasoline components to reduce tailpipe emissions in 39 areas of the United States which exceed the National Ambient Air Quality Standards for carbon monoxide and in the 9 metropolitan regions with the most elevated summertime ozone levels. MTBE and ETBE exposures occur during gasoline production and refueling, and as recently documented in California and Washington, potentially through contact with groundwater contaminated by leaking underground storage tanks. However, little is known about how the body handles MTBE, ETBE and their metabolites; nor about reliable biological indicators or occupational and environmental exposure. We conducted controlled exposures of men and women to 2.5 ppm 2H12-MTBE + 2.5 ppm ETBE for two hours with alternating periods of work and rest, and sampled blood, breath and urine during and for three days following exposure. Concurrently, a physiologically-based kinetic (KBK) model was developed to include data from other research efforts, to incorporate parameter variability through Bayesian fitting and Monte Carlo simulation techniques, and to determine a biological index of exposure Post-exposure blood and breath levels exhibited two half-lives for both 2H12-MTBE and ETBE of about 1 and 8.4 hours, and 1.5 and 10.6 hours, respectively. Tertiary-butyl-alcohol (TBA) breath concentration from each ether appeared to be a valuable index of exposure with a single half-life of 20-40 hours.
Keywords
Pharmacodynamics; Metabolic-study; Metabolic-rate; Metabolism; Metabolites; Blood-analysis; Urinalysis; Biological-monitoring; Biologic-half-life; Biomarkers
Contact
Crispin H Pierce, PhD, University of Washington, Seattle, WA
CAS No.
1634-04-4; 75-65-0; 8006-61-9; 637-92-3
Publication Date
20010501
Document Type
Final Grant Report
Funding Amount
157522
Funding Type
Grant
Fiscal Year
2001
NTIS Accession No.
PB2005-102840
NTIS Price
A04
Identifying No.
Grant-Number-K01-OH-000164
NIOSH Division
OEP
Source Name
National Institute for Occupational Safety and Health
State
WA
Performing Organization
University of Washington, Seattle WA
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