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Validity of a Computer-Assisted Neurobehavioral Test Battery in Toxicant Encephalopathy.

Authors
Proctor-SP; Letz-R; White-RF
Source
Neurotoxicology 2000 Oct, 21(5):703-714
NIOSHTIC No.
20023602
Abstract
The computer-assisted Neurobehavioral Evaluation System 2 (NES2) test battery provides an efficient method of measuring neurobehavioral effects in epidemiological studies, and a newer computer-assisted battery, NES3, has been developed to assist in neuropsychological assessment. This study assesses the validity of some NES2 and NES3 tests in patients diagnosed with toxicant encephalopathy (TE) following exposure to lead or to mixed solvents. This information can be used to improve the interpretation of NES test results in research studies and clinical evaluations examining central nervous system function. Performance on a battery of computer-assisted tests, consisting of several NES2 and NES3 tasks, by persons diagnosed with TE was compared to that of control subjects to determine if performance differences reflected a priori hypothesized brain-behavior relationships. Performance on the NES2 and NES3 tests was also correlated with performance on analogous standard neuropsychological tests. Significant performance differences between the patient cases and controls were observed in most of the predicted domains on the NES tests. Overall, moderate correlations were obtained between standard neuropsychological tests and NES2 and NES3 tests from the same functional domains. The results suggest that a test battery composed of NES2 and NES3 tests can identify clinically significant performance deficits in solvent-exposed patients who have been diagnosed with TE using traditional clinical neuropsychological test methods. The results with lead-exposed TE patients are less robust. Possible explanations for these differences are discussed.
Keywords
Encephalopathy; Behavioral-tests; Epidemiology; Psychological-effects; Lead-compounds; Exposure-levels; Solvents; Central-nervous-system; Psychological-testing
Contact
Susan P. Proctor, D.Sc. Boston Environmental Hazards Center (116B-4), 150 So. Huntington Avenue, Boston, MA 02130, USA
CODEN
NRTXDN
Publication Date
20001001
Document Type
Journal Article
Email Address
sproctor@bu.edu
Funding Amount
160978
Funding Type
Grant
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000136
Issue of Publication
5
ISSN
0161-813X
Source Name
NeuroToxicology
State
MA; GA
Performing Organization
Department of Neurology, Boston University, School of Medicine
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