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A mouse model for hand-arm vibration syndrome.

Authors
Lindsley-WG; Jensen-N; Kommineni-C
Source
Proc 2nd Joint EMBS/BMES Conf, October 23-26, 2002, Houston, Texas, 2002 Oct :448-449
Link
NIOSHTIC No.
20023591
Abstract
Hand-arm vibration syndrome (HAVS) occurs in workers who use vibrating band tools. Symptoms of HAVS include finger paresthesia and numbness, a loss of manual dexterity and grip strength, and vasospasms in the fingers in response to cold. Although the relationship between vibration exposure and HAVS is well-established, it is not clear how vibration causes tissue damage. The purpose of our research is to identify the fundamental physiological mechanisms involved in the development of HAVS. Toward that end, we have developed a vibration exposure system in which mice are placed in a small cage with a rigid floor that vibrates vertically. The system is capable of exposing mice to sinusoidal vibration at 125 to 1250 Hz with accelerations of up to 49 m/s2 rms. Exposures last for 4 hours/day, 5 days/week, for up to 24 weeks. Initial results indicate that 11 weeks of 125 Hz vibration did not significantly affect the body weights of the mice, and that 12 and 24 weeks of vibration did not significantly affect the liver, kidneys, or stomach. These results suggest that this model can be used to examine the effect of vibration on the mouse foot and lower leg without confounding effects from systemic damage.
Keywords
Hand-injuries; Arm-injuries; Vibration; Vibration-disease; Musculoskeletal-system-disorders; Occupational-health; Laboratory-animals; Animal-studies; Animals; Vibration-effects; Vibration-exposure
Publication Date
20021023
Document Type
Conference/Symposia Proceedings
Fiscal Year
2003
NTIS Accession No.
NTIS Price
ISBN No.
0780376129
NIOSH Division
HELD
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Proceedings of the Second Joint EMBS/BMES Conference
State
TX; WV
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