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Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling.

Authors
Tyurina-YY; Tyurin-VA; Shvedova-AA; Fabisiak-JP; Kagan-VE
Source
Methods Enzymol 2002 Jul; 352:159-174
NIOSHTIC No.
20023535
Abstract
Asymmetric distribution of major phospholipid classes across membranes is a fundamental characteristic of all cells whose disturbance is incompatible with physiological functions of membranes and with cell viability. 1,2 Under normal conditions, phosphatidylcholine (PC) and sphingomyelin (SPM) are located primarily in the outer leaflet of plasma membrane, whereas aminophospholipidsphosphatidylethanolamine (PE) and phosphatidylserine (PS)-are found almost entirely in the inner leaflet. 1-3 Transmembrane migration and extemalization of PS by apoptotic cells are considered to be the triggering events for their recognition by cognate "scavenger" receptors of macrophages.4 This is followed by phagocytosis and safe digestion of apoptotic cells, thus preventing development of an inflammatory response.
Keywords
Phospholipids; Physiological-factors; Phagocytes; Phagocytic-activity; Oxidation
CODEN
MENZAU
Publication Date
20020716
Document Type
Journal Article
Email Address
exp3@cdc.gov
Fiscal Year
2002
NTIS Accession No.
NTIS Price
ISBN No.
9780121822552
ISSN
0076-6879
NIOSH Division
HELD
Source Name
Methods in Enzymology
State
WV
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