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A derived association between ambient aerosol surface area and excess mortality using historic time series data.

Authors
Maynard-AD; Maynard-RL
Source
Atmos Environ 2002 Dec; 36(36-37):5561-5567
NIOSHTIC No.
20023497
Abstract
Although aerosol mass concentration is widely associated with ill health following inhalation; there is increasing evidence that it is a poor indicator of fine and ultrafine particle toxicity. Research has indicated that biological response to such particles is closely associated with particulate surface area; although no epidemiology data currently exist to validate the association. By applying a simple model to historic mass-based time series data, we have been able to estimate mortality rate as a function of ambient aerosol surface area. Within the simplifying assumptions of the model, a linear association is indicated between mortality rate and surface area concentration for coalescing particles. The analysis also indicates the existence of a threshold aerosol concentration, below which particulate mass and surface area are linearly related. Below this threshold, we suggest that mass concentration measurements may provide a good indicator of health effects, although for high exposures found in the developing world and industry, the model indicates that aerosol exposure may be more appropriately characterized by surface area. Further experimental validation of the model should establish the applicability of derived relationships between aerosol mass and surface area concentration to ambient and occupational exposures.
Keywords
Aerosols; Mortality-data; Mortality-rates; Inhalation-studies; Particulates; Models; Occupational-exposure; Exposure-levels; Nanotechnology
Contact
US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, OH 45226
CODEN
AENVEQ
Publication Date
20021201
Document Type
Journal Article
Email Address
zel5@cdc.gov
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
36-37
ISSN
1352-2310
NIOSH Division
DART
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
Atmospheric Environment
State
OH
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