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Mortality of industrial workers exposed to acrylonitrile.

Authors
Blair-A; Stewart-PA; Zaebst-DD; Pottern-L; Zey-JN; Bloom-TF; Miller-B; Ward-E; Lubin-J
Source
Scand J Work, Environ & Health 1998 Aug; 24(Suppl 2):25-41
NIOSHTIC No.
20023475
Abstract
This study was designed to evaluate the relationship between occupational exposure to acrylonitrile and cancer mortality. Workers (18079 white men, 4293 white women, 2191 nonwhite men, and 897 nonwhite women) employed in acrylonitrile production or use in the 1950s through 1983 were followed through 1989 for vital status and cause of death. Exposure-response relationships were evaluated from quantitative estimates of historical exposures. Tobacco use was determined for a sample of workers to assess potential confounding. Mortality rates between the exposed and unexposed workers in the cohort were compared using the Poisson regression. Analyses by cumulative, average, peak, intensity, duration, and lagged exposure revealed no elevated risk of cancers of the stomach, brain, breast, prostate or lymphatic and hematopoietic systems. Mortality from lung cancer was elevated for the highest quintile of cumulative exposure. When the decile categories were used, the relative risk did not continue to increase at higher levels. Adjustment for cigarette use reduced the risk for lung cancer only slightly. Separate analyses for wage and salaried workers, long-term and short-term workers, fiber and nonfiber plants, and individual plants revealed no clear exposure-response patterns. The results indicate that exposure to acrylonitrile at the levels studied is not associated with an increased relative risk for most cancers of a priori interest. The excess of lung cancer in the highest quintile of cumulative exposure may indicate carcinogenic activity at the highest levels of exposure, but analyses of exposure-response do not provide strong or consistent evidence for a causal association.
Keywords
Workers; Industrial-exposures; Industrial-gases; Cancer; Lung-cancer; Respiratory-system-disorders; Pulmonary-system-disorders; Humans; Epidemiology; Statistical-analysis; Mortality-rates; Case-studies
Contact
Dr. Aaron Blair, Occupational Epidemiology Branch, National Cancer Institute, Executive Plaza North, Rm. 418, Bethesda, Maryland 20892, United States
CODEN
SWEHDO
CAS No.
107-13-1
Publication Date
19980801
Document Type
Journal Article
Email Address
BLAIRA@epndce.nci.nih.gov
Fiscal Year
1998
NTIS Accession No.
NTIS Price
ISSN
0355-3140
NIOSH Division
DSHEFS
Source Name
Scandinavian Journal of Work, Environment and Health
State
MD; OH; MO
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