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New perspectives in arsenic-induced cell signal transduction.

Authors
Qian-Y; Castranova-V; Shi-X
Source
J Inorg Biochem 2003 Aug; 96(2-3):271-278
NIOSHTIC No.
20023370
Abstract
Although the carcinogenicity of arsenic has been well established, the underlying molecular mechanisms have not yet been fully identified. Accumulating evidence indicates that the alteration of cellular signal transduction is directly related to the carcinogenesis of arsenic. This review focuses on recent advances in arsenic-induced signal transduction, including reactive oxygen species (ROS) production, tyrosine phosphorylation, MAPK signaling, NF-B activation, cell cycle arrest, and apoptosis.
Keywords
Metals; Arsenic-compounds; Cell-alteration; Cell-damage; Cellular-reactions; Carcinogenesis; Carcinogenicity; Metal-compounds
Contact
XYong-Qian, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
JIBIDJ
Publication Date
20030801
Document Type
Journal Article
Email Address
yqian@cdc.gov
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
2-3
ISSN
0162-0134
NIOSH Division
HELD
Source Name
Journal of Inorganic Biochemistry
State
WV
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