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IL-1Beta Gene Polymorphisms Influence Hepatitis B Vaccination.

Authors
Yucesoy-B; Sleijffers-A; Kashon-M; Garssen-J; de Gruijl-FR; Boland-GJ; van Hattum-J; Simeonova-PP; Luster-MI; van Loveren-H
Source
Vaccine 2002 Aug 20(25-26):3193-3196
NIOSHTIC No.
20023346
Abstract
Considerable variability exists in the vaccine response to hepatitis B with 5-10% of healthy young adults demonstrating no or inadequate responses following a standard vaccination schedule. As the interleukin-1beta (IL-1beta) cytokine has been shown to be important in the development of immune responses, we determined whether vaccine efficacy is influenced by genetic polymorphisms associated with IL-1beta expression. Ninety-two healthy individuals who were negative for antibodies to hepatitis B antigen (anti-HBs) were vaccinated against hepatitis B according to a standardized schedule. At selected times, antibody titers and lymphoproliferative capacity to hepatitis B surface antigen (HBsAg) were determined. DNA genotyping for IL-1beta polymorphisms using a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) technique demonstrated that both the anti-HBs titer and the T-cell lymphoproliferative response to HBsAg are significantly increased in individuals possessing the IL-1beta (+3953) minor allelic variant.
Keywords
Liver; Liver-cancer; Infection-control; Infectious-diseases; Viral-infections; Viral-diseases; Bloodborne-pathogens
Contact
National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26508
CODEN
VACCDE
Publication Date
20020819
Document Type
Journal Article
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
25-26
ISSN
0264-410X
NIOSH Division
HELD
Source Name
Vaccine
State
WV
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