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Assessment of the scientific basis for genetic testing of railroad workers with carpal tunnel syndrome.

Authors
Schulte-PA; Lomax-G
Source
J Occup Environ Med 2003 Jun; 45(6):592-600
NIOSHTIC No.
20023241
Abstract
In 2000, approximately 20 railroad track workers who filed injury reports or compensation claims for carpal tunnel syndrome were tested by their employer for two genetic traits to determine the work relatedness of the condition. The testing involved deletions, variants, or mutations in the genetic coding for peripheral myelin protein (PMP22) and transthyretin (TTR). This article is an assessment of whether there is a scientific basis for such testing. A review of the scientific literature indicated that neither the scientific basis nor the population validity of the PMP22 or TTR tests for carpal tunnel syndrome were adequately established before use on railroad track workers in 2000. Although ethical and legal issues may predominate in this case, the absence of a compelling scientific basis undermines the decision to conduct the tests.
Keywords
Genetic-factors; Genetics; Carpal-tunnel-syndrome; Musculoskeletal-system-disorders; Railroad-industry; Screening-methods; Biological-monitoring; Injuries; Work-capability; Medical-screening
Contact
P.A. Schulte, National Institute for Occupational Safety and Health, Mail Stop-C14, 4676 Columbia Parkway, Cincinnati, OH 45226
CODEN
JOEMFM
Publication Date
20030601
Document Type
Journal Article
Email Address
pas4@cdc.gov
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
1076-2752
NIOSH Division
EID
Source Name
Journal of Occupational and Environmental Medicine
State
CA; OH
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