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Parental atopy and asthma in rural children: is there a link?

Authors
Svendsen-ER; Naleway-AL; Thorne-PS; Stromquist-AM; Merchant-JA
Source
Am J Respir Crit Care Med 2003 Apr; 167(7):A853
NIOSHTIC No.
20023110
Abstract
Recent literature has reported low asthma and/or atopy prevalence in rural/farm populations. We found relatively high rates of childhood asthma (16%) and atopy (36%) in a completely rural cohort. The highest prevalence of asthma was in farm children, atopy in rural town children. We tested the hypothesis that parental farm allergies were associated with these outcomes in a cross-sectional study of data from Round I of the Keokuk County Rural Health Study. Parental interview, spirometry, methylcholine inhalation challenge, skin-prick testing, and serum specific IgE (sub-sample only) data were included. This study was limited to 487 children ages 3-17 years. Several specific parental allergy and sensitization variables were associated with asthma or atopy, including farm allergies to hogs (31.0% prev., asthma OR= 1.98, 95%CI 1.21-3.24), soybeans (16.6% prev., asthma OR= 2.48, 95%CI 1.42-4.34), and chickens (8.2% prev., atopy OR= 1.90, 95%CI 0.993.63). After adjustment for other covariates, multiple comparisons within homes, and other environmental exposures; parental allergy to soybeans was associated with increased asthma prevalence in children (OR= 1.12, 95%CI 1.02-1.23). Similarly, parental allergy to chicken was weakly associated with atopy (OR= 1.15, 95%CI 0.99-1.35). Our study suggests that atopy prevalence on farms was low relative to town and rural residents. Parental atopy to farm antigens was a weak contributor to a childs risk of developing atopic illnesses. This abstract does not necessarily represent EPA policy.
Keywords
Bronchial-asthma; Farmers; Children; Allergies; Inhalation-studies; Spirometry; Environmental-exposure; Sensitization; Agricultural-workers; Agriculture; Pulmonary-system-disorders; Respiratory-system-disorders
CODEN
AJCMED
Publication Date
20030401
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
svendsen.erik@epa.gov
Funding Amount
1020020
Funding Type
Cooperative Agreement
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-706145
Issue of Publication
7
ISSN
1073-449X
Priority Area
Pulmonary-system-disorders
Source Name
American Journal of Respiratory and Critical Care Medicine, 2003 International Conference, The American Thoracic Society, Seattle, WA, May 16-21, 2003
State
IA
Performing Organization
University of Iowa, Iowa City, Iowa
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