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Exhaled nitric oxide measurement in microwave popcorn production plant workers.

Authors
Akpinar-Elci-M; Stemple-KJ; Elci-OC; Dweik-RD; Kreiss-K; Enright-PL
Source
Am J Respir Crit Care Med 2003 Apr; 167(7):A840
NIOSHTIC No.
20023109
Abstract
Two former microwave popcorn production plant workers had pathology consistent with bronchiolitis obliterans. The prevalence of respiratory problems and airways obstruction among current workers were higher than expected. Exhaled nitric oxide (ENO) was measured in workers at risk for developing lung disease. One hundred thirty five workers completed a questionnaire, spirometry and ENO measurement. Workers with relatively high exposures (n= 107, mixing, microwave packaging, maintenance, and quality control) were compared to workers with low exposure from other areas of the plant (n= 28). ENO was lower in the 135 current workers (median 5.9 ppb) when compared to an external control group of 31 healthy never smokers (median 7.6 ppb) (p=0.001). ENO was lower in the high-risk group of workers (median 5.5 ppb) when compared to the low risk group (median 6.6 ppb) (p=0.03). There were no significant associations between ENO and current respiratory symptoms or lung function. However, after adjusting for smoking status, workers with current systemic symptoms were more likely than other workers to have a high ENO [chills OR: 7.8 (95% CI: 1.1-58.3); night sweats OR: 8.3 (95% CI: 1.1-64.6); fever OR: 4.0 (95% CI: 0.9-18.3)]. In this study of microwave popcorn workers, ENO was not useful for distinguishing between groups of workers with and without respiratory symptoms or lung function abnormalities. However, the association of ENO with systemic symptoms suggests that ENO might be useful in the study of inhalation fever or other inhalation syndromes.
Keywords
Nitrates; Oxides; Respiratory-system-disorders; Airway-obstruction; Lung-disease; Pulmonary-system-disorders; Questionnaires; Spirometry; Lung-function; Occupational-exposure; Chest-X-rays; Respiratory-irritants; Airway-resistance; Age-groups; Smoking; Air-sampling; Air-quality-monitoring; Chronic-exposure; Pulmonary-function; Pulmonary-disorders; Respirable-dust; Food-processing-workers; Food-processing-industry; Food-processing; Food-additives
CODEN
AJCMED
CAS No.
10102-43-9
Publication Date
20030401
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
mra8@cdc.gov
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
7
ISSN
1073-449X
NIOSH Division
DRDS
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
American Journal of Respiratory and Critical Care Medicine, 2003 International Conference, The American Thoracic Society, Seattle, WA, May 16-21, 2003
State
WV; OH
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