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Isocyanate-based spray-paint exposure and change in lung function.

Authors
Glindmeyer-H; Rando-R; Lefante-J; Freyder-L; Hnizdo-E; Friedman-M; Jones-R
Source
Am J Respir Crit Care Med 2003 Apr; 167(7):A839
NIOSHTIC No.
20023106
Abstract
A cross-sectional study of spray-painters was conducted to quantify adverse respiratory effects of exposure to polyurethane enamels using HDI-based isocyanates. The population consisted of 287 spray-painters at 4 facilities. Each subject was administered a spirometric test and a medical, smoking, and occupational questionnaire (including spray-painting history and respirator usage). Total and respirable personal samples (n= 152) were collected during spray-painting. For each subject, cumulative exposures were computed for total and respirable paint aerosol (TPA & RPA) and isocyanate in total and respirable aerosol (TIA & RIA) as arithmetic mean facility exposure, times years painting. Multiple linear regression was used to relate percent predicted (PP) FEV1, FVC, FEV1/FVC, and FEF25-75 to cumulative exposure, after adjusting for age, cigarette smoking, asthma and respiratory protection. Cumulative exposures in (mg/m3)-years ranged up to 578.0 TPA, 57.6 RPA, 69.4 TIA and 6.9 RIA. For all exposure indices, after adjusting for smoking, asthma and respiratory protection, higher exposure was significantly associated with reduced PPFEV1, PPFEV1/FVC, and PPFEF25-75. Significant Smoking-related reductions were observed for PPFEV1, PPFEV1/FVC, and PPFEF25-75. Respirator usage was associated with significantly higher PPFEV1 and PPFVc. No significant smoking and exposure interactions were noted. Adjusting for asthma resulted in a significant reduction in PPFVC only, with no effect on the significance of exposure. Exposure levels were within total and respirable "nuisance dust" standards, but were significantly associated with adverse effects. Respiratory protection was beneficial, but more stringent exposure controls are required for spray-painting with polyurethane enamels.
Keywords
Isocyanates; Lung-function; Respiratory-system-disorders; Polyurethane-foams; Questionnaires; Smoking; Occupational-exposure; Respirators; Aerosol-particles; Aerosols; Respiratory-protection; Bronchial-asthma; Respirable-dust; Pulmonary-system-disorders; Spray-painting; Paint-spraying; Painters; Surveillance
CODEN
AJCMED
Publication Date
20030401
Document Type
Abstract; Conference/Symposia Proceedings
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
7
ISSN
1073-449X
NIOSH Division
DRDS
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease; Construction
Source Name
American Journal of Respiratory and Critical Care Medicine, 2003 International Conference, The American Thoracic Society, Seattle, WA, May 16-21, 2003
State
WV; LA
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