Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Comparison of Two Methods for Sampling Hexamethylene Diisocyanate Biuret Aerosol: A Chamber Study.

Authors
Liu-Y; Bello-D; Redlich-CA; Stowe-MH; Cullen-MR; Walsh-FX; Young-F; Woskie-SR
Source
Am J Respir Crit Care Med 2003 Apr; 167(7):A716
NIOSHTIC No.
20023083
Abstract
Hexamethylene diisocyanate (HDI) biuret aerosol exposure is an important cause of occupational asthma. Control in the workplace is hampered by lack of agreement on the best metric for quantifying exposure and a uniform analytical method. A new NIOSH method 5525 has recently been developed that uses the Institute of Occupational Medicine sampler, a single quartz filter and 1-(9-anthracenylmethyl)piperazine (MAP) as derivatizing agent. The purpose of this study was to compare this method with the established ISOCHEK (ISO) cassette method in measuring HDI biuret aerosol. A closed exposure chamber was used to generate an HDI biuret (Desmodur N-l00) aerosol with overall concentrations varied over an equivalent HDI monomer range of 4 to 70 ppb, as measured by the Autostep portable equipment. Twenty-seven side-by-side samples were taken from the chamber using both methods. Samples were analyzed by high performance liquid chromatography. For HDI monomer, MAP method found higher levels than ISO method [GM (GSD:ug/m3): 80.1(2.2) vs. 61.3(2.0), p<0.005, n=27]. For HDI biuret aerosol, MAP method found lower levels [75.4(2.7) vs. 99.0(3.3),p<0.05, n=25]. When exposure was expressed as total reactive isocyanate group (TRIG) mass, no difference was found between MAP and ISO methods [65.6(2.0) vs. 61.2(2.1), p>0.05, n=25]. MAP method was also found best correlated with ISO method for biuret aerosol (ISO = 1.06MAP, R2=0.78). These results suggest that measurements of HDI aerosol by MAP and ISO methods were similar although the data were variable. The MAP method potentially provides an easier alternative for the measurement of HDI and HDI-based polyisocyanate aerosol.
Keywords
Aerosols; Occupational-exposure; Analytical-methods; Workplace-studies; Aerosol-particles; Sampling-methods; Analytical-instruments
CODEN
AJCMED
CAS No.
110-82-7; 822-06-0; 108-19-0
Publication Date
20030401
Document Type
Abstract; Conference/Symposia Proceedings
Funding Amount
2634676
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003457
Issue of Publication
7
ISSN
1073-449X
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
American Journal of Respiratory and Critical Care Medicine, 2003 International Conference, The American Thoracic Society, Seattle, WA, May 16-21, 2003
State
CT; MA
Performing Organization
Yale University, New Haven, CT
TOP