Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Single and repeated zinc-oxide exposure in asthma: effect on airway inflammation.

Authors
Reintjes-K; Witten-A; Balmes-J; Blanc-P; Solomon-C
Source
Am J Respir Crit Care Med 2003 Apr; 167(7):A505
NIOSHTIC No.
20023063
Abstract
Single and repeated exposure to zinc-oxide (ZnO) results in an increase in inflammatory cells and cytokines in healthy individuals. The chronic airway inflammation in asthma could increase ZnO-induced inflammation, however this is unknown. This experiment was designed to test the hypothesis that exposure to ZnO on two consecutive days would decrease both the cellular and cytokine responses, compared to one exposure, in individuals with asthma. Utilizing a repeated measure, counter-balanced, single-blind design, 10 subjects with asthma (8 females; age range 22-47 yr; methacholine PC20 < 5 mg ml) were exposed for 30 min, at rest, to: 1) filtered-air (FA); 2) ZnO; one exposure (ZnO-1: 10 mg m3); 3) ZnO; two exposures (ZnO-2: 10 mg m3). Sputum induction (3% saline, t = 20 min) was performed 65 h pre- and 6 h post-exposure. Comparisons were made within (pre- vs post-exposure), and between-conditions (post- minus pre-exposure delta). Within ZnO-1, there was a significant (P<0.05) increase in the neutrophil percent (median; 25-75% range: 67.3; 58.9-74.6 vs 38.1; 26.7-68.5%), the delta of which, compared to FA, was increased (18.6; 5.7-26.7 vs -1.8; -7.7-7.7%). In ZnO-2, compared to FA, there was a significant increase in the total leukocyte concentration (175; 125-240 vs 89; 61-133 x l04 cells ml), andTNFa (5.9; 3.6-25.0 vs 0.; 0.01.4 pg ml). There were no significant differences in any variables between ZnO-1 and ZnO-2. These results indicate that in individuals with asthma, both single and repeated exposure to ZnO causes an increase in indices of inflammation, but that the specific cell and protein changes could be different as a function of the exposure format.
Keywords
Zinc-compounds; Exposure-levels; Airway-obstruction; Airway-resistance; Cellular-reactions; Air-filters; Respiratory-system-disorders; Pulmonary-system-disorders; Bronchial-asthma
CODEN
AJCMED
CAS No.
1314-13-2
Publication Date
20030401
Document Type
Abstract; Conference/Symposia Proceedings
Funding Amount
977554
Funding Type
Cooperative Agreement
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative Agreement-T42-CCT-910427
Issue of Publication
7
ISSN
1073-449X
Priority Area
Disease and Injury; Asthma and Chronic Obstructive Pulmonary Disease
Source Name
American Journal of Respiratory and Critical Care Medicine, 2003 International Conference, The American Thoracic Society, Seattle, WA, May 16-21, 2003
State
CA
Performing Organization
Center for Occupational and Environmental Health, University of California, Berkeley, California
TOP