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Induction of apoptosis from instillation of agricultural dust.

Authors
Mercer-RR; Wang-L; Antonini-JM; Scalilloni-JF; Vallyathan-V; Castranova-V
Source
FASEB J 2002 Mar; 16(5):A962
NIOSHTIC No.
20023059
Abstract
In this study, we test the hypothesis that induction of alveolar macrophages (AM) apoptosis plays a role in lung injury from particulates. We examined AM apoptosis in F344 rats following intratracheal instillation of 1ml of saline containing 4mg of particles. Particles used include crystalline silica, titanium dioxide and particulates from air sampling of citrus and grape fields. After 4 weeks, rats were sacrificed and lung sections analyzed for the number of apoptotic cells per lung using TdT labeling. Apoptotic macrophages, expressed in millions of cells per lung (mean+SE,N=4) were 43.4+4 for crystalline silica, 10.50+0.2 for grape, 8.1+0.5 for citrus and 3.1+0.4 for titanium dioxide. Saline controls were 1.6+0.4. The degree of apoptosis correlated well with inflammation and damage suggesting a role for apoptosis in lung injury resulting from particulates.
Keywords
Lung-function; Lung-disorders; Particulates; Alveolar-cells; Animal-studies; Silicates; Air-samples; Laboratory-animals; Respiratory-system-disorders; Pulmonary-system-disorders; Agriculture; Dust-exposure; Dust-particles; Dusts; Agricultural-industry; Particulate-dust; Silica-dusts; Air-sampling; Animals; Lung-irritants
Contact
NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
FAJOEC
CAS No.
14808-60-7; 13463-67-7
Publication Date
20020322
Document Type
Abstract; Conference/Symposia Proceedings
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0892-6638
NIOSH Division
HELD
Source Name
The FASEB Journal, Experimental Biology 2002, New Orleans, Louisiana, April 20-24, 2002
State
WV; LA
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