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Restraint stress and corticotropin releasing hormone modulation of murine cutaneous POMC mRNA.

Authors
Flint-MS; Morgan-JB; Shreve-SN; Tinkle-SS
Source
Stress 2003 Mar; 6(1):59-62
Link
NIOSHTIC No.
20023049
Abstract
The skin is a unique immunological defense barrier that protects the organism from occupational and environmental exposures and provides a model system in which to evaluate the interaction of the central nervous system with the peripheral immune response. In the studies presented here, we tested mild, acute restraint stress activation of the cutaneous corticotropin releasing hormone-pro-opiomelanocortin (CRH-POMC) axis. We verified that 2 h restraint stress increased the serum concentration of corticosterone and alpha-melanocyte stimulating hormone. We report for the first time that CRH upregulates POMC mRNA expression in mouse skin in vitro. We also demonstrated, by RT-PCR, that 2,4 di-nitrofluorobenzene (DNFB) upregulates cutaneous POMC mRNA expression, the production of which is suppressed by restraint stress. These data confirm the presence and functionality of two hormones of the hypothalamo-pituitary axis in the skin and suggest that activation of the central hypothalamo-pituitary-adrenal axis may over ride activation of the cutaneous CRH-POMC mechanism in the development of DNFB-stimulated allergic contact dermatitis.
Keywords
Skin-protection; Skin-exposure; Central-nervous-system; Immune-reaction; In-vitro-studies; Animal-studies; Laboratory-animals; Pituitary-glands; Adrenal-cortex; Adrenocortical-response; Dermatitis; Contact-dermatitis; Allergic-dermatitis
Contact
Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
CAS No.
581-05-5; 66796-54-1; 70-34-8; 9015-71-8
Publication Date
20030301
Document Type
Journal Article
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1025-3890
NIOSH Division
HELD
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
Stress: The International Journal on the Biology of Stress
State
WV
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