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Influence of hyperthyroidism on rat lung cytokine production and nuclear factor (NF)-KappaB activation following ozone exposure.

Authors
Huffman-LJ; Prugh-D; Brumbaugh-K; Ding-M
Source
FASEB J 2002 Mar; 16(5):A961-A962
NIOSHTIC No.
20023048
Abstract
Results from previous studies indicate that hyperthyroidism increases the risk of ozone-induced lung toxicity. In the present study, we evaluated cytokine levels in bronchoalveolar lavage fluid from control and hyperthyroid male rats 18 hours after exposure to air or ozone (2 ppm for 3 hours). MIP-2 and MCP-I levels were increased in both control and hyperthyroid rats following ozone. However, the increase in hyperthyroid rats were much greater, MIP-2 (I.S fold) and MCP-I (II fold), when compared to levels in controls. These changes appeared to be relatively specific; bronchoalveolar lavage fluid levels of IL-6, IL-4, and IL-IO were generally low or non-detectable across all groups at this time. We also found that NF-kappa B binding activity was increased at both 4 and 18 hours following ozone exposure in bronchoalveolar lavage cell extracts from hyperthyroid rats relative to controls. Collectively, these results suggest that mechanisms contributing to the enhanced pulmonary inflammatory response to ozone in a hyperthyroid state include an increase in NF-Kappa B activation and an up-regulation of chemokine production.
Keywords
Lung-irritants; Lung-disorders; Lung-function; Lung-tissue; Animal-studies; Pulmonary-system; Pulmonary-function; Pulmonary-system-disorders; Laboratory-animals; Respiratory-system-disorders; Endocrine-system-disorders; Exposure-levels; Environmental-exposure; Toxic-effects; Lung-disease; Air-monitoring
CODEN
FAJOEC
CAS No.
10028-15-6
Publication Date
20020322
Document Type
Abstract; Conference/Symposia Proceedings
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0892-6638
NIOSH Division
HELD
Source Name
The FASEB Journal, Experimental Biology 2002, New Orleans, Louisiana, April 20-24, 2002
State
WV; LA
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