Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Time-course of functional and pathological changes in chlorine exposed A/J mice.

Authors
Campbell-HR; Ramos-Barbon-D; Tuck-SA; Martin-JG
Source
Am J Respir Crit Care Med 2002 Apr 165(8)(Suppl):A522
NIOSHTIC No.
20023021
Abstract
Inhalation of irritants such as chlorine (CI,) can lead to the development of irritant induced asthma. Few animal models have been developed to study the effects of CI, on airway) cellular responses and changes in lung function. To investigate in vivo the effects of CI2 on airway inflammation and lung function, NJ mice were exposed to inhaled CI, (400 ppm) for 5 min. Animals were assessed 24h, 48h and 7 d after exposure by measuring respiratory system resistance (RRS) and elastance (ELRS) in response to i.v. methacholine (MCh). BAL was performed to determine total and differential cell counts and epithelial cell shedding. To determine the effects of inhibiting iNOS, a group of animals was treated with I400W in addition to being exposed to Cl, (400 ppm) for 5 minutes and studied 24 h after 0, exposure. Maximal inflammatory response to Cl, was observed 24 h after CI, expos... and was characterized by increased BAL total cell counts (n=6; p<0.001), granulocytes (n=6;p<0.002), macrophages (n=6;p<0.001) and epithelial cells (n=6;p
Keywords
Inhalants; Chlorine-compounds; Respiratory-system-disorders; Pulmonary-system-disorders; Cellular-function; Lung-function; Animal-studies; In-vivo-study; Laboratory-animals
CODEN
AJCMED
CAS No.
7782-50-5
Publication Date
20020401
Document Type
Abstract; Conference/Symposia Proceedings
Funding Amount
375000
Funding Type
Grant
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004058
Issue of Publication
8
ISSN
1073-449X
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
American Journal of Respiratory and Critical Care Medicine, 2002 International Conference, The American Thoracic Society, Atlanta Georgia, May 17-22, 2002
Performing Organization
Hospital du Sacre-Coeur, Montreal, Quebec
TOP