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Arsenic carcinogenicity: relevance of c-Src activation.

Authors
Simeonova-PP; Luster-MI
Source
Mol Cell Biochem 2002 May-Jun; 234-235(1-2):277-282
NIOSHTIC No.
20022966
Abstract
Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation.
Keywords
Arsenic-compounds; Carcinogenicity; Genes; Skin-cancer; Bladder-cancer; Occupational-exposure; Environmental-exposure; Respiratory-system-disorders; Tumors; Cell-growth; Liver; Kidneys
Contact
P.P. Simeonova, NIOSH; HELD; TMBB, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505-2888, USA
CODEN
MCBIB8
CAS No.
7440-38-2
Publication Date
20020501
Document Type
Journal Article
Email Address
phs9@cdc.gov
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0300-8177
NIOSH Division
HELD
Source Name
Molecular and Cellular Biochemistry
State
WV
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