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Evaluation of self-reported skin problems among workers exposed to toluene diisocyanate (TDI) at a foam manufacturing facility.

Authors
Daftarian-HS; Lushniak-BD; Reh-CM; Lewis-DM
Source
J Occup Environ Med 2002 Dec 44(12):1197-1202
NIOSHTIC No.
20022950
Abstract
Toluene diisocyanate, or TDI (CAS 584-84-9) is a well-known asthmagen and respiratory irritant. TDI is also known for its ability to irritate the skin and mucous membranes. To further investigate the dermal effects of TDI, NIOSH investigators conducted a cross-sectional study at a flexible foam manufacturing plant. A total of 114 workers participated in the study. Participants completed a medical questionnaire, provided blood for antibody testing to TDI and other allergens, and a subset of participants reporting skin symptoms underwent skin patch testing to a standard diisocyanate panel. Production line workers were more than twice as likely to report skin problems as those working in nonproduction areas (PRR = 2.66; 95% CI = 1.14-16.32; P = 0.02). Age, gender and duration of employment at the plant were comparable among participants working in production and nonproduction areas. Of the 100 participants who provided blood samples for antibody testing, specific IgG antibody to TDI was detected in two individuals, and none of the samples demonstrated specific IgE antibody to TDI. Of the 26 workers who underwent skin patch testing, none developed reactions to the diisocyanate allergens. These results suggest that the skin symptoms among study participants represent an irritant rather than an immunologic reaction to TDI, or to an unidentified allergen present in the foam.
Keywords
Toluenes; Respiratory-irritants; Skin-irritants; Mucous-membranes; Questionnaires; Allergens; Demographic-characteristics; Age-factors; Blood-samples; Respiratory-system-disorders; Pulmonary-system-disorders
Contact
Helga S. Daftarian, DO, MPH, Medical Director, Health Services Department, General Motors North America Moraine Assembly Plant, 2601 W. Stroop Road, Dayton, OH 45439-1929
CODEN
JOEMFM
CAS No.
584-84-9
Publication Date
20021201
Document Type
Journal Article
Email Address
helga.daftariando@gm.com
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
12
ISSN
1076-2752
NIOSH Division
HELD; DSHEFS
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
Journal of Occupational and Environmental Medicine
State
OH; WV
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