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Evaluation of allergen sensitivity by skin prick testing and specific IgE in asthmatic children and matched controls in a rural cohort.

Authors
Thorne-PS; Kelly-KM; Metwali-N; Stromquist-A; Merchant-JA
Source
Am J Respir Crit Care Med 2002 Apr 165(8)(Suppl):A127
NIOSHTIC No.
20022919
Abstract
The prevalence of childhood asthma has been increasing markedly in both urban and rural populations. We studied 100 rural asthmatic Iowa children and matched controls, ages 13.4+-3.3, in order to establish risk factors for allergy and asthma. In this analysis, we compared skin prick testing (SPT) with allergen-specific IgE (slgE) ELISA to determine if future studies could rely on serum analyses alone Fewer than 4% of subjects were SPT positive for corn smut, grain smut, mixed molds, mixed tree pollens, chicken feathers, horse, hog, cattle, dog, and soybeans. Greater than 4% were positive for house dust mites, cat, cockroach, mixed weed and mixed grass pollens. Among asthma cases, Sage positivist was as follows: 31-34% for house dust mites (Der f 1 and Der p 1),24% for cockroaches, 24% for cat hair, and 6% for weed pollens. All except Der p 1 had significantly higher positivity among asthmatics. Analysis of total IgE and slgE was conducted on serum samples drawn concurrently with SPT. Total lgE levels were significantly higher in asthmatics than control subjects (p=0.01). Among asthma cases, slgE positivity was as follows: 31-32% for house dust mites (Der p 1 and Der f 1), 18% for cockroaches, 36% for Fel d 1, 32% for weed pollens, 29% for Asp f 1 and 18% for mixed tree pollens. Concordance between SPT and slgE positivity for the six allergens common to both was 84- 90%. Conclusion: These data suggest that serum analysis may provide sufficient information on allergy in children such that researchers need not perform SPT.
Keywords
Children; Allergies; Allergic-reactions; Skin-tests; Serology; Serological-techniques; Pulmonary-system-disorders; Respiratory-system-disorders; Allergens
CODEN
AJCMED
Publication Date
20020401
Document Type
Abstract; Conference/Symposia Proceedings
Funding Amount
199712
Funding Type
Grant
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-CCR-714364
Issue of Publication
8
ISSN
1073-449X
Source Name
American Journal of Respiratory and Critical Care Medicine, 2002 International Conference, The American Thoracic Society, Atlanta Georgia, May 17-22, 2002
State
IA; MD
Performing Organization
College of Public Health, University of Iowa, Iowa City, Iowa
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