Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Ototoxic effects of styrene alone or in concert with other agents: a review.

Authors
Morata-TC; Campo-P
Source
Noise Health 2002 Jan-Mar; 4(14):15-24
NIOSHTIC No.
20022794
Abstract
Styrene is an organic solvent employed in many manufacturing industries, as well as in other economic sectors. Recently, evidence is beginning to accumulate on the hazardous effects that styrene exposures have on the auditory system. In rats, a well-suited metabolic animal model for these studies, aromatic solvents seem to affect the auditory sensitivity mainly in the cochlear mid-frequency range. Outer hair cells are the primary targets within the organ of Corti, although the spiral ganglions are not spared. Therefore, styrene must be considered as an ototoxic chemical agent that can be potentially neurotoxic. Finally, noise-styrene exposures can have synergistic effects on the auditory system. The findings reported in both human and animal studies indicate that exposures to styrene, or to styrene associated to noise, may dramatically impact occupational hearing conservation practices and legislation. Human and animal studies will be summarized in discussing the effects of styrene alone or in combination with noise and other chemicals. Gaps in scientific knowledge are highlighted to assist future research.
Keywords
Styrenes; Occupational-exposure; Ototoxicity; Respiratory-system-disorders; Lung-disease; Respiratory-rate; Skin-irritants; Neuropathology; Plastics-industry; Hearing; Inhalation-studies; Solvents; Hearing-conservation; Synergism
Contact
National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway/MS:C27 Cincinnati, Ohio 45226-1998
CODEN
NHOEA4
CAS No.
71-43-2; 100-41-4; 100-42-5
Publication Date
20020101
Document Type
Journal Article
Email Address
tmorata@cdc.gov
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
14
ISSN
1463-1741
NIOSH Division
DART
Priority Area
Disease and Injury: Hearing Loss
Source Name
Noise & Health
State
OH
TOP