Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Chronic obstructive pulmonary disease due to occupational exposure to silica dust: a review of epidemiological and pathological evidence.

Authors
Hnizdo-E; Vallyathan-V
Source
Occup Environ Med 2003 Apr; 60(4):237-243
NIOSHTIC No.
20022791
Abstract
Occupational exposure is an important risk factor for chronic obstructive pulmonary disease (COPD), and silica dust is one of the most important occupational respiratory toxins. Epidemiological and pathological studies suggest that silica dust exposure can lead to COPD, even in the absence of radiological signs of silicosis, and that the association between cumulative silica dust exposure and airflow obstruction is independent of silicosis. Recent clinicopathological and experimental studies have contributed further towards explaining the potential mechanism through which silica can cause pathological changes that may lead to the development of COPD. In this paper we review the epidemiological and pathological evidence relevant to the development of COPD in silica dust exposed workers within the context of recent findings. The evidence surveyed suggests that chronic levels of silica dust that do not cause disabling silicosis may cause the development of chronic bronchitis, emphysema, and/or small airways disease that can lead to airflow obstruction, even in the absence of radiological silicosis.
Keywords
Respiratory-system-disorders; Pulmonary-system-disorders; Dust-inhalation; Dusts; Dust-exposure; Air-flow; Silica-dusts; Aerosols; Smoking; Cigarette-smoking; Tobacco-smoke; Surveillance
Contact
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
OEMEEM
Publication Date
20030401
Document Type
Journal Article
Email Address
Exh6@cdc.gov
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
1351-0711
NIOSH Division
DRDS; HELD
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease; Work Environment and Workforce: Mixed Exposures; Construction
Source Name
Occupational and Environmental Medicine
State
WV
TOP