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Pregnancy hormone metabolite patterns, pregnancy symptoms, and coffee consumption.

Authors
Lawson-CC; LeMasters-GK; Levin-LS; Liu-JH
Source
Am J Epidemiol 2002 Sep; 156(5):428-437
NIOSHTIC No.
20022763
Abstract
Because of contradictory reports of pregnancy outcomes and coffee intake, this study was designed to determine how hormone metabolite levels, symptoms, and coffee consumption patterns are related. Eligible subjects were recruited in Cincinnati, Ohio, from 1996 to 1998, aged 1840 years, and nonsmokers; drank at least 18 ounces (1 ounce = 29.6 ml) of coffee per week (including decaffeinated) at the last menstrual period; and were enrolled by 9 weeks from the last menstrual period. Beverage consumption and pregnancy symptoms were recorded daily. Weekly, first-morning urine samples were collected to assess human chorionic gonadotropin, estrone-3-glucuronide, and pregnanediol-3-glucuronide. A time-dependent, repeated measures analysis was performed to test several associations. Data from 92 subjects were analyzed with the following results. 1) Coffee consumption was significantly, inversely associated with weekly levels of estrone-3-glucuronide and human chorionic gonadotropin. 2) Weekly hours of nausea were significantly, directly associated with human chorionic gonadotropin and inversely with estrone-3-glucuronide and pregnanediol-3-glucuronide. 3) Weekly coffee consumption was significantly associated with vomiting but not with nausea or appetite loss. 4) Weekly levels of pregnanediol-3-glucuronide were 32.2% lower in subjects who drank at least 8 ounces of coffee/day at the last menstrual period, though above what was necessary to maintain those pregnancies. This study shows the significance of these important variables to be considered in future research.
Keywords
Gonadotropic-hormones; Pregnancy; Prenatal-exposure; Hormones; Hormone-activity; Metabolites; Estrogenic-hormones; Time-weighted-average-exposure
Contact
National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop R-15, Cincinnati Oh 45226-1998
CODEN
AJEPAS
Publication Date
20020901
Document Type
Journal Article
Email Address
CLawson@cdc.gov
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0002-9262
NIOSH Division
DSHEFS
Priority Area
Disease and Injury: Fertility and Pregnancy Abnormalities
Source Name
American Journal of Epidemiology
State
OH
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