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Cytokine polymorphisms in chronic inflammatory diseases with reference to occupational diseases.

Authors
Yucesoy-B; Kashon-ML; Luster-MI
Source
Curr Mol Med 2003 Feb; 3(1):39-48
NIOSHTIC No.
20022658
Abstract
Genes which encode inflammatory cytokines are subject to polymorphisms in their regulatory regions that may effect both the level and ratio of cytokines produced in response to exogenous stimuli. These variant alleles are observed in a large percent of the population and are often associated with increased or decreased susceptibility or severity (modifiers) to infectious, immune or inflammatory diseases. Environmental factors can also play either a direct (i.e., causative factor) or indirect (modifying factor) role in these diseases. Thus, it would follow that gene-environment interactions would effect the expression and/or progression of the disease. In the present review, the concept that some of the common allelic variants found in cytokine genes represent modifying factors in chronic inflammatory diseases associated with occupational exposure is discussed.
Keywords
Genes; Diseases; Infectious-diseases; Environmental-factors; Occupational-exposure; Chronic-inflammation; Pulmonary-system-disorders; Beryllium-disease; Occupational-health; Hepatitis; Dermatitis; Genetics; Genetic-factors
Contact
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
CMMUBP
Publication Date
20030201
Document Type
Journal Article
Email Address
BYucesoy@cdc.gov
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1566-5240
NIOSH Division
HELD
Source Name
Current Molecular Medicine
State
WV
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