Wearing chemical-resistant gloves and clothing is the primary method used to prevent skin exposure to toxic chemicals in the workplace. The process for selecting gloves is usually based on manufacturers' laboratory-generated chemical permeation data. However, such data may not reflect conditions in the workplace where many variables are encountered (e.g., elevated temperature, flexing, pressure, and product variation between suppliers). Thus, the reliance on this selection process is questionable. Variables that may influence the performance of chemical-resistant gloves are identified and discussed. Passive dermal monitoring is recommended to evaluate glove performance under actual-use conditions and can bridge the gap between laboratory data and real-world performance.