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Otoneurotoxic effects of solvents: review of the literature.

Authors
Demange-V; Chouaniere-D; Loquet-G; Perrin-P; Johnson-AC; Morata-T
Source
Otorhinolaryngol Nova 2001 Jan; 11(3-4):141-150
NIOSHTIC No.
20022611
Abstract
Organic solvents are used in the industrial environment, and the combined exposure to noise and solvents (pure or in mixtures) is of concern to numerous workers from various economic sectors. Although the effects of organic solvents on the central nervous system are well known, their sensorineural effects, particularly in the auditory system, constitute a new area for research. Studies conducted with experimental animals have shown that the combined exposure to solvents and noise results in a synergistic effect on the auditory system, and that the lesions can be both cochlear and retrocochlear. In humans, there is now evidence from epidemiological studies in the occupational environment suggesting an ototoxic effect of some single solvents and solvent mixtures, as well as evidence of an interaction between noise and solvents on the auditory function. Published in French.
Keywords
Ototoxicity; Neurotoxic-effects; Neurotoxicity; Solvents; Organic-solvents; Noise; Toluenes; Styrenes; Xylenes
Contact
D. Chouaniere, Department d'Epidemiologie en Entreprises, INRS, Avenue de Bourgogne, BP 27, F-54 501 Vandoeuvre-les-Nancy (France)
CAS No.
100-42-5; 108-88-3; 79-01-6; 1330-20-7
Publication Date
20010101
Document Type
Journal Article
Email Address
chouaniere@inrs.fr
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
3-4
ISSN
1014-8221
NIOSH Division
DART
Priority Area
Neurotoxic Effects; Neurotoxic Disorders
Source Name
Oto-Rhino-Laryngologia Nova
State
OH
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