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Benzene exposure and hematopoietic mortality: a long-term epidemiologic risk assessment.

Authors
Rinsky-RA; Hornung-RW; Silver-SR; Tseng-CY
Source
Am J Ind Med 2002 Dec; 42(6):474-480
NIOSHTIC No.
20022389
Abstract
Previous studies of a cohort of rubber hydrochloride workers indicated an association between benzene exposure and excess mortality from leukemia and multiple myeloma. To determine whether risks remain elevated with increasing time since plant shutdown, we extended follow-up from 1981 through 1996. We evaluated risk using standardized mortality ratios (SMR) and generalized Cox proportional hazards regression models. Five new leukemia cases were observed in benzene-exposed white males, but the summary SMR for this group declined from 3.37 (95% CI = 1.54-6.41) to 2.56 (95% CI = 1.43-4.22). In regression models, cumulative exposure was significantly associated with elevated relative risks for leukemia mortality. Four new multiple myeloma deaths occurred, three of which were in workers judged to be unexposed. These findings reaffirm the leukemogenic effects of benzene exposure and suggest that excess risk diminishes with time.
Keywords
Risk-analysis; Risk-factors; Rubber-workers; Benzenes; Epidemiology; Leukemogenesis; Worker-health; Workplace-monitoring; Occupational-exposure; Mortality-data; Mortality-rates
Contact
National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, 4676 Columbia Parkway, MS R-44, Cincinnati, OH 45226, USA
CODEN
AJIMD8
CAS No.
71-43-2
Publication Date
20021201
Document Type
Journal Article
Email Address
Robert.Rinsky @chmcc.org
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0271-3586
NIOSH Division
DSHEFS
Source Name
American Journal of Industrial Medicine
State
OH
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