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Effect of follow-up time on risk estimates: a longitudinal examination of the relative risks of leukemia and multiple myeloma in a rubber hydrochloride cohort.

Authors
Silver-SR; Rinsky-RA; Cooper-SP; Hornung-RW; Lai-D
Source
Am J Ind Med 2002 Dec; 42(6):481-489
NIOSHTIC No.
20022388
Abstract
Choice of follow-up time for an occupational cohort can influence risk estimates. We examined the effects of follow-up time on relative risk estimates for leukemia and multiple myeloma in a cohort of 1,845 rubber hydrochloride workers. We generated standardized mortality ratios (SMRs) for yearly follow-ups, beginning each study in 1940 and increasing study end dates from 1950 through 1996. We used Cox proportional hazards modeling to explore the effects of follow-up time on the exposure-response relationship. The SMR for leukemia rose to 13.55 in 1961 and fell nearly monotonically to 2.47 by 1996. Cox modeling suggested interaction between cumulative exposure and time since exposure. A longer time to peak risk was seen for multiple myeloma. Because summary risk estimates change with follow-up time, exposure limits set using these estimates may not adequately protect workers. Consideration of appropriate follow-up time and use of more complex temporal models are critical to the risk assessment process.
Keywords
Risk-analysis; Risk-factors; Rubber-workers; Benzenes; Epidemiology; Leukemogenesis; Worker-health; Workplace-monitoring; Occupational-exposure; Mortality-data; Mortality-rates
Contact
National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies,4676 Columbia Parkway,MS R-44, Cincinnati,OH 45226, USA
CODEN
AJIMD8
CAS No.
71-43-2
Publication Date
20021201
Document Type
Journal Article
Email Address
ZRE4 @cdc.gov
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0271-3586
NIOSH Division
DSHEFS
Source Name
American Journal of Industrial Medicine
State
OH
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