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Effects of whole body vibration on pulmonary function in rats.

Authors
Frazer-D; McKinney-W; Stolarik-B; Reynolds-J; Rosenberry-K; Afshari-A
Source
Biomedical Engineering: Recent Developments, J. Vossoughi, Ed., Medical and Engineering Publishers, Inc. 2002 Sep :365-366
Link
NIOSHTIC No.
20022353
Abstract
Exposure to vibration stress occurs in numerous occupational settings (e.g. construction, agriculture, mining) where an increase in pulmonary disease has been observed. The objective of this study was to determine if vibration stress alters pulmonary function. Rats (N=10), housed in individual cylindrical chambers, received sinusoidal vibration in a horizontal plane (head to tail) for 4 hrs. at a frequency of 5 Hz and a peak acceleration of 0.75 G. Control rats (N=10) were housed in similar chambers but were not subjected to vibration. During each exposure period, animals received HEP A filtered, conditioned air. Breathing rates and PenH were measured prior to exposure, immediately following exposure, and 18 hrs. post exposure. Respiratory input impedance was measured (SCIREQ, tlexiVent) prior to and during a methacholine challenge for anesthetized animals at 18 hrs. post exposure. Although there were no significant differences in baseline respiratory input impedance, animals receiving whole body vibration were hyporesponsive to methacholine at 18 hrs. post exposure. "
Keywords
In-vitro-studies; Vibration; Vibration-exposure; Pulmonary-function-tests; Pulmonary-system; Respiratory-system-disorders
Publication Date
20020901
Document Type
Book or book chapter; Conference/Symposia Proceedings
Editors
Vossoughi-J
Fiscal Year
2002
NTIS Accession No.
NTIS Price
ISBN No.
1930636016
NIOSH Division
HELD
Priority Area
Work Environment and Workforce: Mixed Exposures; Research Tools and Approaches: Exposure Assessment Methods
Source Name
Biomedical Engineering: Recent Developments
State
WV
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