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Development of quantitative exposure data for a pooled exposure-response analysis of 10 silica cohorts.

Authors
Mannetje-A; Steenland-K; Checkoway-H; Koskela-R; Koponen-M; Attfield-M; Chen-J; Hnizdo-E; DeKlerk-N; Dosemci-M
Source
Am J Ind Med 2002 Aug; 42(2):73-86
NIOSHTIC No.
20022283
Abstract
Comprehensive quantitative silica exposure estimates over time, measured in the same units across a number of cohorts, would make possible a pooled exposure-response analysis for lung cancer. Such an analysis would help clarify the continuing controversy regarding whether silica causes lung cancer. Existing quantitative exposure data for 10 silica-exposed cohorts were retrieved from the original investigators. Occupation- and time-specific exposure estimates were either adopted/adapted or developed for each cohort, and converted to milligram per cubic meter (mg/m(3)) respirable crystalline silica. Quantitative exposure assignments were typically based on a large number (thousands) of raw measurements, or otherwise consisted of exposure estimates by experts (for two cohorts). Median exposure level of the cohorts ranged between 0.04 and 0.59 mg/m(3) respirable crystalline silica. Exposure estimates were partially validated via their successful prediction of silicosis in these cohorts. Existing data were successfully adopted or modified to create comparable quantitative exposure estimates over time for 10 silica-exposed cohorts, permitting a pooled exposure-response analysis. The difficulties encountered in deriving common exposure estimates across cohorts are discussed.
Keywords
Silicates; Exposure-levels; Quantitative-analysis; Mineral-processing; Mine-workers; Cancer-rates; Lung-cancer; Lung-disease; Quartz-dust; Silica-dusts
Contact
Kyle Steenland, NIOSH R13, DHHS, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226
CODEN
AJIMD8
CAS No.
14808-60-7; 61790-53-2
Publication Date
20020802
Document Type
Journal Article
Email Address
kns1@cdc.gov
Funding Amount
381670
Funding Type
Grant
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003126
Issue of Publication
2
ISSN
0271-3586
NIOSH Division
DRDS; DART
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
American Journal of Industrial Medicine
State
OH; CA; VT; SD; WA
Performing Organization
University of Washington, Seattle, Washington
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