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Intracellular signal transduction of cells in response to carcinogenic metals.

Authors
Chen-F; Shi-X
Source
Crit Rec Oncol Hematol 2002 Apr; 42(1):105-121
NIOSHTIC No.
20022254
Abstract
Epidemiological and animal studies suggest that several metals and metal-containing compounds are potent mutagens and carcinogens. These metals include chromium, arsenic, vanadium, nickel, and others. During the last two decades, chemical and cellular studies have contributed enormously to our understanding of the mechanisms of metal-induced pathophysiological processes. Although each of these metals is unique in its mechanism of action, some common signaling molecules, such as reactive oxygen species (ROS), may be shared by many of the carcinogenic metals. New techniques are now available to reveal the mechanisms of carcinogenesis in precise molecular terms. In this review, we focused our attentions on carcinogenic metal-induced signal transduction pathways leading to the activation of NF-kappaB, cell apoptosis and cell cycle progression, three crucial steps or events involved in the transformation and carcinogenesis. This review summarizes current knowledge and our recent studies concerning intracellular signal transduction pathways initiated by carcinogenic metals and the cross-talk that occurs among these pathways in cells in response to metals.
Keywords
Animal-studies; Cell-alteration; Cell-growth; Metal-compounds; In-vivo-studies; In-vitro-studies; Cell-transformation; Genes
Contact
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
CCRHEC
CAS No.
7440-47-3; 1327-53-3; 7440-48-4; 7440-50-8; 7440-02-0; 1314-34-7; 7440-38-2; 1333-82-0; 1314-62-1
Publication Date
20020401
Document Type
Journal Article
Email Address
lfd3@cdc.gov; xshi@cdc.gov
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1040-8428
NIOSH Division
HELD
Priority Area
Research Tools and Approaches: Cancer Research Methods
Source Name
Critical Reviews in Oncology Hematology
State
WV
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