Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species.
Environ Health Perspect 2002 Oct; 110(Suppl 5):807-811
The nuclear factor kappa B (NF-kappaB) family of transcription factors controls expression of a number of early response genes associated with inflammatory responses, cell growth, cell cycle progression, and neoplastic transformation. These genes include a multitude of cytokines, chemokines, adhesion molecules, immune receptors, stress proteins, apoptotic or anti-apoptotic regulators, and several oncogenes. Accumulating evidence indicates that a variety of toxic metals are able to affect the activation or activity of NF-kappaB, but the molecular mechanisms involved in this process remain largely unknown. The signaling pathways mediating cytokine- or microorganism-induced NF-kappaB activation have been well established recently. Whether the same signaling systems are involved in metal-induced NF-kappaB activation, however, is unclear. In the present review, we have attempted to evaluate and update the possible mechanisms of metal signals on the activation and function of NF-kappaB.
Epidemiology; Carcinogens; Cancer; Ultraviolet-light; Metallic-poisons; Metal-poisoning; Heavy-metal-poisoning; Heavy-metals
F. Chen, PPRB/NIOSH, 1095 Willowdale Rd., Morgantown, WV 26505
7440-38-2; 7440-02-0; 1327-53-3; 1333-82-0; 1314-62-1
Research Tools and Approaches: Cancer Research Methods
Environmental Health Perspectives