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Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species.

Authors
Chen-F; Shi-X
Source
Environ Health Perspect 2002 Oct; 110(Suppl 5):807-811
NIOSHTIC No.
20022253
Abstract
The nuclear factor kappa B (NF-kappaB) family of transcription factors controls expression of a number of early response genes associated with inflammatory responses, cell growth, cell cycle progression, and neoplastic transformation. These genes include a multitude of cytokines, chemokines, adhesion molecules, immune receptors, stress proteins, apoptotic or anti-apoptotic regulators, and several oncogenes. Accumulating evidence indicates that a variety of toxic metals are able to affect the activation or activity of NF-kappaB, but the molecular mechanisms involved in this process remain largely unknown. The signaling pathways mediating cytokine- or microorganism-induced NF-kappaB activation have been well established recently. Whether the same signaling systems are involved in metal-induced NF-kappaB activation, however, is unclear. In the present review, we have attempted to evaluate and update the possible mechanisms of metal signals on the activation and function of NF-kappaB.
Keywords
Epidemiology; Carcinogens; Cancer; Ultraviolet-light; Metallic-poisons; Metal-poisoning; Heavy-metal-poisoning; Heavy-metals
Contact
F. Chen, PPRB/NIOSH, 1095 Willowdale Rd., Morgantown, WV 26505
CODEN
EVHPAZ
CAS No.
7440-38-2; 7440-02-0; 1327-53-3; 1333-82-0; 1314-62-1
Publication Date
20021001
Document Type
Journal Article
Email Address
lfd@cdc.gov
Fiscal Year
2003
NTIS Accession No.
NTIS Price
ISSN
0091-6765
NIOSH Division
HELD
Priority Area
Research Tools and Approaches: Cancer Research Methods
Source Name
Environmental Health Perspectives
State
WV
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