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Beryllium disease natural history and exposure-response.

Authors
Newman-LS
Source
NIOSH 2002 Jan; :1-17
Link
NIOSHTIC No.
20022216
Abstract
BeS progresses to CBD at a rate of 7-11 % per year. Beryllium-sensitized patients merit medical counseling and surveillance for signs of progression to disease. Medical surveillance identifies individuals with CBD of whom 22% progress to treatment with steroids. Parameters that seem to best predict progression specific to CBD are changes in forced vital capacity (FVC) over time and changes in A-a gradient with exercise. More than 50% of the beryllium machining particles in the breathing zone were less than 10 m in aerodynamic diameter. This small particle size may result in beryllium deposition into the deepest portion of the lung and may explain elevated rates of sensitization among beryllium machinists. A high percentage of the particles generated during machining are less than 0.6microm in aerodynamic diameter and from 8% to 10% of the aerosol generated may be deposited in the deep portions of the lung. Measurable beryllium contamination on workers hands and inside their vehicles indicates that take-home beryllium exposure is still a significant risk. Worker risk notification programs can positively affect workers self-protective attitudes and behaviors.
Keywords
Occupational-respiratory-disease; Lung-disease; Respiratory-system-disorders; Blood-analysis; Work-environment; Genetic-factors; Lymphocytes; Bronchial-cancer; Biological-effects
Contact
National Jewish Medical and Research Center, Division of Environmental and Occupational Health Sciences, 1400 Jackson street, Denver, CO 80206
CAS No.
7440-41-7
Publication Date
20020124
Document Type
Final Cooperative Agreement Report
Funding Amount
1980104
Funding Type
Cooperative Agreement
Fiscal Year
2002
NTIS Accession No.
PB2004-104522
NTIS Price
A03
Identifying No.
Cooperative-Agreement-Number-U60-CCU-812221
Source Name
National Institute for Occupational Safety and Health
State
CO
Performing Organization
National Jewish Medical and Research Center, Division of Environmental and Occupational Health Sciences, Denver, Colorado
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