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Immunotoxicology of organic acid anhydrides (OAAs).

Authors
Zhang-XD; Siegel-PD; Lewis-DM
Source
Int Immunopharmacol 2002 Feb; 2(2-3):239-248
NIOSHTIC No.
20022204
Abstract
Organic acid anhydrides (OAAs) have considerable economic importance due to their extensive use in the production of alkyd, epoxy, and polyester resins. Occupational exposure to OAAs has been associated with a variety of health effects, which may be classified into two major categories of direct toxicity/irritant and hypersensitivity. The hypersensitivity diseases associated with OAA exposure are thought to be related to the reactivity of these chemicals and in particular their ability to form protein conjugates that may be recognized as neo-antigens by the immune system. This review will present a brief discussion of the basic chemistry of these compounds and the environmental and biological monitoring methods used for exposure measurements. The clinical syndromes associated with exposure to these compounds will be discussed along with factors that may affect disease susceptibility. Finally, animal models that have been developed to examine the mechanisms of disease will be discussed.
Keywords
Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disease; Organic-acids; Anhydrides; Animal-studies; Alveolar-cells; Immunotoxins; Occupational-respiratory-disease; Hypersensitivity; Immune-system; Allergic-disorders; Epoxy-resins; Antibody-response; Toxic-effects; Proteins
Contact
Analytical Services Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
CAS No.
108-31-6; 85-44-9; 552-30-7
Publication Date
20020201
Document Type
Journal Article
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
2-3
ISSN
1567-5769
NIOSH Division
HELD
Source Name
International Immunopharmacology
State
WV
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