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Diseases caused by silica: mechanisms of injury and disease development.

Authors
Ding-M; Chen-F; Shi-X; Yucesoy-B; Mossman-B; Vallyathan-V
Source
Int Immunopharmacol 2002 Feb; 2(2-3):173-182
NIOSHTIC No.
20022203
Abstract
While silica particles are considered to be fibrogenic and carcinogenic agents, the mechanisms responsible are not well understood. This article summarizes literature on silica-induced accelerated silicosis, chronic silicosis, silico-tuberculosis, bronchogenic carcinoma, and immune-mediated diseases. This article also discusses the generation of reactive oxygen species (ROS) that occurs directly from the interaction of silica with aqueous medium and from silica-stimulated cells, the molecular mechanisms of silica-induced lung injuries with focus on silica-induced NF-kappaB activation, including its mechanisms, possible attenuation and relationship to silica-induced generation of cyclooxygenase II and TNF-alpha. Silica-induced AP-1 activation, protooncogene expression, and the role of ROS in these processes are also briefly discussed.
Keywords
Silica-dusts; Fibrogenesis; Carcinogenesis; Silicosis; Bronchial-cancer; Immune-system-disorders; Respiratory-system-disorders; Pharmacodynamics; Pulmonary-system-disorders; Physiopathology; Cell-alteration; Lung-cells; Lung-disease; Oncogenic-agents; Oxygen-uptake; Free-radical-generation; Free-radicals
Contact
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Publication Date
20020201
Document Type
Journal Article
Email Address
vav1@cdc.gov
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
2-3
ISSN
1567-5769
NIOSH Division
HELD
Source Name
International Immunopharmacology
State
WV
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