Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Pulmonary alterations associated with inhalation of occupational and environmental irritants.

Authors
Castranova-V; Frazer-DG; Manley-LK; Dey-RD
Source
Int Immunopharmacol 2002 Feb; 2(2-3):163-172
NIOSHTIC No.
20022190
Abstract
Many gases, vapors, or particles found in occupational and/or environmental settings can act as irritants. In the present study, sensory irritants are characterized by the stimulation of neuropeptide release from sensory nerves in the nasal mucosa, while pulmonary irritants are characterized by recruitment of PMN into bronchoalveolar airspaces, elevation of breathing frequency, and neuropeptide release from sensory fibers innervating the epithelium of the conducting airways. A review of data from our laboratory as well as results from others indicate that asphalt fume is a sensory irritant; toluene diisocyanate (TDI), methyl isocyanate, and machining fluid act as both sensory and pulmonary irritants; while cotton dust, agricultural dusts, microbial products, leather conditioner, and ozone exhibit responses characteristic of pulmonary irritants.
Keywords
Pulmonary-system-disorders; Nasal-disorders; Occupational-respiratory-disease; Breathing; Animal-studies; Laboratory-animals; Sensory-motor-system; Respiratory-irritants; Cotton-dust; Microorganisms; In-vitro-studies
Contact
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
CAS No.
584-84-9; 624-83-9; 10028-15-6
Publication Date
20020201
Document Type
Journal Article
Email Address
vic1@cdc.gov
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
2-3
ISSN
1567-5769
NIOSH Division
HELD
Priority Area
Work Environment and Workforce: Mixed Exposures
Source Name
International Immunopharmacology
State
WV
TOP