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IgG subclass responses in experimental silicosis.

Authors
Weissman-DN; Hubbs-AF; Huang-SH; Stanley-CF; Rojanasakul-Y; Ma-JKH
Source
J Environ Pathol Toxicol Oncol 2001 Jan; 20(Suppl 1):67-74
NIOSHTIC No.
20021926
Abstract
Silicosis is a crippling fibrotic lung disease induced by inhaling crystalline silica. In addition to fibrosis, silica inhalation by humans is associated with a number of immunological effects including increased levels of serum immunoglobulins (in particular IgG), increased prevalence of autoantibodies, and autoimmune disease. Recent studies using rodent models have shown that experimental silicosis is associated with a T-helper (TH)1 pattern of T-cell activation in the lungs and lung-associated lymph nodes after silica inhalation, which are also the sites of increased IgG production. We therefore hypothesized that the subclass distribution of IgG production occurring in experimental silicosis would suggest TH1 activation as the primary stimulus for IgG production. Using an ELISPOT assay, we found increased IgG-secreting spot-forming cells of all IgG subclasses in lung-associated lymph nodes taken from silica-exposed rats 3 to 4 months after aerosol exposure to silica. Neither TH1- nor TH2-dependent IgG subclass-secreting cells were selectively enhanced. Our findings suggest that TH1 activation alone does not account for increased production of IgG in experimental silicosis.
Keywords
Silicosis; Quartz-dust; Lung-disease; Silica-dusts; Fibrosis; Lymph-nodes; Silicates; Lung-fibrosis; Pulmonary-system-disorders; Respiratory-system-disorders; Immunologic-disorders; Diseases; Laboratory-animals; Animals; Animal-studies; Exposure-assessment; Author Keywords: silicosis; quartz; IgG; lymphocyte; cytokine; lung
Contact
National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Analytical Services Branch, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
JEPOEC
CAS No.
14808-60-7
Publication Date
20010101
Document Type
Journal Article
Email Address
dqw4@cdc.gov
Fiscal Year
2001
NTIS Accession No.
NTIS Price
ISSN
0731-8898
NIOSH Division
HELD
Source Name
Journal of Environmental Pathology, Toxicology, and Oncology
State
WV
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