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Roles of glia in developmental neurotoxicity: session VI summary and research needs.

Authors
Tiffany-Castiglioni-E; Guerri-C; Aschner-M; Matsushima-GK; O'Callaghan-JP; Streit-WJ
Source
Neurotoxicology 2001 Oct; 22(5):567-73
NIOSHTIC No.
20021894
Abstract
The purpose of this session was to address the molecular, pathological, and functional responses of astroglia, microglia, and oligodendroglia to neurotoxicant exposure. Neurons are the signaling cells of the nervous system, and as such are responsible for the perception of sensory stimuli and the coordination of cellular, tissue, and organismal responses to stimuli from the environment. Neuronal function and nervous tissue structure requires the participation of neuroglia, or glia, including astroglia (which participate in neurotransmitter metabolism and responses to stress and injury), radial glia and Bergmann glia (which provide scaffolding for neuronal migration during development), oligodendroglia and Schwann cells (which myelinate axons in the central and peripheral nervous systems, respectively), and microglia (which mediate inflammatory responses in the central nervous system). The roles of each of these cells as target cells and participants in various aspects of developmental neurotoxicity was discussed.
Keywords
Neurotoxicity; Pathology; Nervous-system; Stimulants; Environmental-exposure; Central-nervous-system
CODEN
NRTXDN
Publication Date
20011001
Document Type
Journal Article
Editors
Cranmer-JM
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0161-813X
NIOSH Division
HELD
Priority Area
Other Occupational Concerns; Neurotoxic Disorders
Source Name
Neurotoxicology
State
FL; NC; TX; WV
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