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Risk assessment for 2,3,7,8-p-dioxin (TCDD) based on an epidemiologic study.

Authors
Steenland-K; Deddens-J; Piacitelli-L
Source
Am J Epidemiol 2001 Sep; 154(5):451-458
NIOSHTIC No.
20021878
Abstract
The International Agency for Research on Cancer (Lyon, France) recently concluded that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a human carcinogen. There have been few human studies and risk assessments with quantitative exposure data. The authors previously conducted exposure-response analyses based on estimated external TCDD exposure for 3,538 US male chemical workers and found a positive trend for all cancer with increasing cumulative exposure. In the present study, 1988 data from 170 workers with both estimated external exposure and known serum TCDD levels were used to derive the relation between the two. This derived relation was used to estimate serum TCDD levels over time for all 3,538 workers, and new dose-response analyses were conducted by using cumulative serum level. A positive trend (p = 0.003) was found between estimated log cumulative TCDD serum level and cancer mortality. For males, the excess lifetime (75 years) risk of dying of cancer given a TCDD intake of 1.0 pg/kg of body weight per day, twice the background intake, was an estimated 0.05-0.9% above a background lifetime risk of cancer death of 12.4%. Data from this cohort are consistent with another epidemiologic risk assessment from Germany and support recent conclusions by the US Environmental Protection Agency.
Keywords
Dioxins; Carcinogens; Exposure-assessment; Exposure-levels; Exposure-limits; Workplace-studies; Work-environment; Risk-analysis; Chemical-industry-workers; Chemical-factory-workers; Factory-workers; Industrial-exposures; Industrial-factory-workers
Contact
Dr. Kyle Steenland, Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226-1998
CODEN
AJEPAS
CAS No.
1746-01-6
Publication Date
20010901
Document Type
Journal Article
Email Address
kns1@cdc.gov
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0002-9262
NIOSH Division
DSHEFS
Source Name
American Journal of Epidemiology
State
OH
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