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MAP kinase activation in macrophages.

Authors
Rao-KMK
Source
J Leukoc Biol 2001 Jan; 69(1):3-10
NIOSHTIC No.
20021846
Abstract
Stimulation of macrophages by a variety of agents causes activation of mitogen-activated protein kinases (MAPKs). Activation of MAPKs by lipopolysaccharide involves CD14 and Toll receptors. Subsequent steps still remain to be explored. Tumor necrosis factor-alpha (TNF-alpha)-induced activation of MAPKs has been shown to involve the death domain proteins (TRADD, FADD, MADD) and TRAFs. Other molecules involved in this pathway include the protein kinases, ASK1, germinal center kinase (GCK), hematopoietic progenitor kinase 1 (HPK1), and GCK-related kinase (GCKR). Although, these pathways have been described in various cell types, their role in macrophages remains to be established. The availability of knockout mice and constitutively active and dominant-negative mutants of MAPKs should greatly enhance our understanding of this field. The activation of MAPKs seems to be different in cell lines compared with primary cells. Among the macrophages, cells from different compartments show different expression of receptors and signal transduction molecules. These differences may account for differences in MAPK activation and other phenotypic differences in macrophages from different compartments. Therefore, it is important to use primary cells for studying MAPK signal-transduction pathways, and the data from cell lines should not be extrapolated to primary cells.
Keywords
Proteins; Cell-biology; Physiology; Cell-differentiation; Alveolar-cells
Contact
K. Murali Krishna Rao, M.D., Box 2015, PPRB/HELD/National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
JLBIE7
Publication Date
20010101
Document Type
Journal Article
Email Address
mir8@cdc.gov
Editors
Stewart-CC
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0741-5400
NIOSH Division
HELD
Priority Area
Exposure Assessment Methods; Surveillance Research Methods
Source Name
Journal of Leukocyte Biology
State
WV
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