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Ultrafine beryllium number concentration as a possible metric for chronic beryllium disease risk.

Authors
McCawley-MA; Kent-MS; Berakis-M
Source
Appl Occup Environ Hyg 2001 May; 16(5):631-638
NIOSHTIC No.
20021810
Abstract
Beryllium is a lightweight metal which causes a chronic granulomatous lung disease among workers who become sensitized to it. Recent research has shown a persistence of the disease despite efforts at control with mean exposures below the Occupational Safety and Health Administration (OSHA) occupational exposure limit of 2 microg/m3. Results of our current research confirm a previous finding in certain plants that particle number concentrations are higher in areas where historical estimate of risk showed a high risk of disease despite relatively lower mass concentrations. By providing side-by-side measurements of both particle number and mass, this research adds support to the proposal that particle number rather than particle mass may be more reflective of target organ dose and subsequently a more appropriate measure of exposure for chronic beryllium disease. Our evidence also shows that particle mass exposure measurements and particle number exposure measurements were not correlated.
Keywords
Lung-disease; Beryllium-disease; Sensitization; Occupational-exposure; Aerosols; Beryllium-compounds; Risk-factors; Risk-analysis; Diseases; Metals; Respiratory-system-disorders; Pulmonary-system-disorders; Exposure-limits; Exposure-levels; Nanotechnology; Author Keywords: Beryllium; Chronic Beryllium Disease; Beryllium Sensitization; Lung Deposition; Particle Size; Occupational Exposure; Ultrafine Aerosol
Contact
Michael A. McCawley, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia
CODEN
AOEHE9
CAS No.
7440-41-7
Publication Date
20010501
Document Type
Journal Article
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
1047-322X
NIOSH Division
DRDS
Source Name
Applied Occupational and Environmental Hygiene
State
WV; OH
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