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Role of inflammation in chemical-induced hepatotoxicity.

Authors
Luster-MI; Simeonova-PP; Gallucci-RM; Bruccoleri-A; Blazka-ME; Yucesoy-B
Source
Toxicol Lett 2001 Mar; 120(1-3):317-321
NIOSHTIC No.
20021799
Abstract
The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseases, such as autoimmunity, are responsible for producing mediators that can effect liver damage or repair. This review will summarize our current understanding of how inflammatory processes influence hepatic pathology and repair following exposure to established hepatotoxic chemicals including carbon tetrachloride, an industrial chemical, and acetaminophen, a widely used analgesic.
Keywords
Liver-damage; Liver-function; Hepatotoxins; Analgesics; Immunotoxins; Hepatotoxicity; Toxic-effects; Toxins; Diseases; Exposure-levels; Hepatotoxins; Analgesics
Contact
Michael I. Luster, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505, USA
CODEN
TOLED5
CAS No.
56-23-5
Publication Date
20010331
Document Type
Journal Article
Email Address
mluster@cdc.gov
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
1-3
ISSN
0378-4274
NIOSH Division
HELD
Source Name
Toxicology Letters
State
WV; OK; NY
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