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In vivo reduction of chromium (VI) and its related free radical generation.

Authors
Liu-KJ; Shi-X
Source
Mol Cell Biochem 2001 Jun; 222(1-2):41-47
NIOSHTIC No.
20021795
Abstract
Chromium (VI) compounds are widely recognized as human carcinogens. Extensive studies in vitro and in model systems indicate that the reactive intermediate, Cr (V), generated by cellular reduction of Cr (VI), is likely the candidate for the ultimate carcinogenic form of chromium compounds. Here we review our current understanding of the in vivo reduction of Cr (VI) and its related free radical generation. Our results demonstrate that Cr (V) is indeed generated from the reduction of Cr (VI) in vivo, and that Cr (V) thus formed can mediate the generation of free radicals. Cr (V) and its related free radicals are very likely to be involved in the mechanism of Cr (VI)-induced toxicity and carcinogenesis. These studies also illustrate that in vivo EPR spectroscopy and magnetic resonance imaging can be very useful and powerful tools for studying paramagnetic metal ions in chemical and biochemical reactions occurring in intact animals.
Keywords
Free-radicals; Chromium-compounds; Carcinogens; Metallic-ions; In-vivo-studies; Free-radical-generation; In-vitro-studies; Models; Carcinogenesis; Carcinogenicity; Biochemical-analysis
CODEN
MCBIB8
CAS No.
7440-47-3
Publication Date
20010601
Document Type
Journal Article
Email Address
jliu@unm.edu
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0300-8177
NIOSH Division
HELD
Source Name
Molecular and Cellular Biochemistry
State
WV; NM
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