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Distribution of HER2 V655 genotypes in breast cancer cases and controls in the United States.

Authors
Keshava-C; McCanlies-EC; Keshava-N; Wolff-MS; Weston-A
Source
Cancer Lett 2001 Nov; 173(1):37-41
NIOSHTIC No.
20021770
Abstract
The minor variant frequency of a HER2 polymorphism (HER2(V655)) has been determined for 471 United States women enrolled in a multiracial case-control study. Allelic frequencies varied significantly by race. Genotypic distributions showed no excess breast cancer risk associated with inheritance of HER2(V655) either as carriers (OR=1.2, 95% CI=0.8-1.9), heterozygotes (OR=1.2, 95% CI=0.8-1.9), or homozygotes (OR=1.4, 95% CI=0.4-4.2). Nor was there a significant association when each racial group was considered separately. The current study suggests the HER2(V655) allele is not a breast cancer risk factor for Caucasians, African-Americans, or Latinas.
Keywords
Breast-cancer; Neoplasms; Demographic-characteristics; Racial-factors; Controlled-environment; Cancer; Case-studies; Sex-factors; Risk-factors; Risk-analysis; Epidemiology; Statistical-analysis
Contact
Ainsley Weston, National Institute for Occupational Safety and Health - CDC, 1095 Willowdale Road, MS-L3014, Morgantown, WV 26505, USA
CODEN
CALEDQ
Publication Date
20011108
Document Type
Journal Article
Email Address
agw8@cdc.gov
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0304-3835
NIOSH Division
HELD
Source Name
Cancer Letters
State
WV
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