Distribution of HER2 V655 genotypes in breast cancer cases and controls in the United States.
Keshava-C; McCanlies-EC; Keshava-N; Wolff-MS; Weston-A
Cancer Lett 2001 Nov; 173(1):37-41
The minor variant frequency of a HER2 polymorphism (HER2(V655)) has been determined for 471 United States women enrolled in a multiracial case-control study. Allelic frequencies varied significantly by race. Genotypic distributions showed no excess breast cancer risk associated with inheritance of HER2(V655) either as carriers (OR=1.2, 95% CI=0.8-1.9), heterozygotes (OR=1.2, 95% CI=0.8-1.9), or homozygotes (OR=1.4, 95% CI=0.4-4.2). Nor was there a significant association when each racial group was considered separately. The current study suggests the HER2(V655) allele is not a breast cancer risk factor for Caucasians, African-Americans, or Latinas.
Breast-cancer; Neoplasms; Demographic-characteristics; Racial-factors; Controlled-environment; Cancer; Case-studies; Sex-factors; Risk-factors; Risk-analysis; Epidemiology; Statistical-analysis
Ainsley Weston, National Institute for Occupational Safety and Health - CDC, 1095 Willowdale Road, MS-L3014, Morgantown, WV 26505, USA