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Antioxidant mechanisms of nitric oxide against iron-catalyzed oxidative stress in cells.

Authors
Kagan-VE; Kozlov-AV; Tyurina-YY; Shvedova-AA; Yalowich-JC
Source
Antioxid Redox Signal 2001 Apr; 3(2):189-202
NIOSHTIC No.
20021764
Abstract
Three distinct antioxidant pathways are considered through which iron-catalyzed oxidative stress may be regulated by nitric oxide (NO). The first two pathways involve direct redox interactions of NO with iron catalytic sites and represent a fast response that may be considered an emergency mechanism to protect cells from the consequences of acute and intensive oxidative stress. These are (i) NO-induced nitrosylation at heme and non-heme iron catalytic sites that is capable of directly reducing oxoferryl-associated radicals, (ii) formation of nitrosyl complexes with intracellular "loosely" bound redox-active iron, and (iii) an indirect regulatory pathway that may function as an adaptive mechanism that becomes operational upon long-term exposure of cells to NO. In the latter pathway, NO down-regulates expression of iron-containing proteins to prevent their catalytic prooxidant reactions.
Keywords
Antioxidants; Oxides; Stress; Proteins; Reaction-rates; Oxidative-processes; Iron-oxides; Exposure-levels
CODEN
ARSIF2
Publication Date
20010401
Document Type
Journal Article
Email Address
kagan@pitt.edu
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1523-0864
NIOSH Division
HELD
Source Name
Antioxidants & Redox Signaling
State
WV; PA
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