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Transactivation of RARE and GRE in the cellular response to arsenic.

Authors
Huang-C; Li-J; Ding-M; Costa-M; Castranova-V; Vallyathan-V; Ju-G; Shi-X
Source
Mol Cell Biochem 2001 Jun; 222(1-2):119-125
NIOSHTIC No.
20021752
Abstract
Arsenic compounds are a somewhat unique class of metals, which have been considered as both carcinogens and chemotherapeutic agents for cancers. Tumor promotion effects of arsenic are believed to be associated with its transactivational activities on transcription factors, such as AP-1 and NFkappaB, while the induction of cell apoptosis and differentiation by arsenic is considered to be a mechanism for the chemotherapeutic effects of arsenic. Here, we found that exposure of cells to arsenite and arsenate leads to transactivation of retinoic acid response elements (RARE) and glucocorticoid response elements (GRE) in mouse epidermal JB6 cells. These inductions occur in a time-dependent manner. Furthermore, induction of RARE activity by arsenic was synergistically enhanced by co-treatment of cells with retinoic acid, while GRE activation by arsenic was not affected by combined treatment of cells with fluocinolone acetonide (FA). In consideration of the important role of RARE and GRE in induction of cell differentiation, we speculate that transactivation of RARE and GRE by arsenic may be involved in its induction of cell differentiation and anti-cancer activities in addition to its induction of apoptosis.
Keywords
Cellular-reactions; Arsenic-compounds; Arsenates; Metals; Carcinogens; Cancer; Exposure-levels; Exposure-assessment; Arsenites; Laboratory-animals; Animals; Animal-studies
Contact
Nelson Institute of Environmental Medicine, New York University School of Medicine, NY 10016
CODEN
MCBIB8
CAS No.
7440-38-2; 15502-74-6
Publication Date
20010601
Document Type
Journal Article
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0300-8177
NIOSH Division
HELD
Priority Area
Cancer; Disease and Injury
Source Name
Molecular and Cellular Biochemistry
State
NY; WV
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